B.A. English, magna cum laude, Willamette University
Ph.D. neuroscience, University of Wisconsin – Madison
Post-doctoral study, neuropharmacology, Emory University
Mind and Brain (NSC 201)
Neurons and Networks (NSC 311)
Advanced Seminar in Neuroscience (NSC 401)
Neurotransmitter Receptor Structure and Function (NSC 380)
Concepts of Biology: Drugs and Drug Abuse (BIO 115)
First Year Seminar: Other Bodies (DNA 108)
Pregnane neurosteroids are dynamically regulated in the central nervous system during stress, menstruation, and pregnancy. Recent studies indicate that metabolites of progesterone such as allopregnanolone (ALLO) exert their anxiolytic effects on the gamma-aminobutyric acid Type A (GABAA) receptor, the major inhibitory neurotransmitter receptor. In my laboratory, we are interested in mapping the ALLO binding site on this receptor. Early studies suggest that changing the subunit composition of the receptor affects its sensitivity to ALLO. My laboratory uses a multidisciplinary approach, including biochemical, pharmacological, and physiological techniques, to resolve the molecular underpinnings of neurosteroid modulation of the GABAA receptor. Understanding the structure and function of this binding pocket will help us understand how ALLO may underlie the anxiety evoked during premenstrual syndrome, post-partum depression, and post-traumatic stress disorder. Additionally, these data may also yield important new information about the hormonal control of inhibitory circuitry in the central nervous system.
Recent Publications and
Jablonski AM '08, Toboul E '07, Matulay JT '08, Lashner MA and Teissére JA (2008) Resolving the functional relationship of allopregnanolone to the identity of amino acids in the M1 region of the GABAA receptor a1 subunit. Washington, DC: Society for Neuroscience 2008 Annual Meeting. Online.
Sancar F, Ericksen SS, Kucken AM, Teissere JA and Czajkowski C (2007)
Structural determinants for high-affinity zolpidem binding to GABAA receptors. Mol Pharmacol 71:38-46.
Sheard LB '07, McGinniss JE '06 and Teissére JA (2006) Dissecting neurosteroid modulation of the GABAA receptor using interreceptor chimeragenesis. Atlanta, GA: Society for Neuroscience 2006 Annual Meeting. Online.
Balasubramanian S, Teissére JA, Raju DV and Hall RA (2004) Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking. J Biol Chem 279:18840-18850.
Kucken AM*, Teissére JA*, Kucken AM, Seffinga-Clark J, Wagner DA and Czajkowski C (2002) Structural requirements for imidazobenzodiazepine binding to GABAA receptors. Mol Pharmacol 63:289-296. (*Denotes equal first author contribution)
Teissére JA and Czajkowski C (2001) A beta-strand in the g2 subunit lines the benzodiazepine binding site of the GABAA receptor: Structural rearrangements detected during channel gating. J Neurosci 21:4977-4986.